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464 papers

Why LivePositively Stands Out

densazavador · Oct 15, 2026

LivePositively is a content platform designed for people who value practical information, thoughtful articles, and useful ideas for everyday life. Instead of focusing on a single niche, the site brings together material on wellbeing, lifestyle, personal growth, education, travel, home, sustainability, and other topics that appeal to a broad audience.

livepositivelylive positively

Application of PAX7 Gene Therapy for Muscle Wound Healing and Regeneration

min578 · Oct 14, 2026

Muscle injuries, ranging from minor exercise-induced tears to severe injuries, necessitate effective recovery strategies to restore tissue functions. This study integrates a comprehensive literature review with gene ontology-based analysis to identify the candidate genes involved in the muscle repair process. The key genes, including VEGF, TGF-β, and the IGF family, were identified for their roles in muscle cell regeneration during angiogenesis, myogenesis, and satellite cell activation. The overlapping analysis further highlighted NOTCH1, ENO3, MSTN, MYF6, and notably PAX7 as potential therapeutic targets for gene therapy. Focused cell experiments demonstrated that overexpression of PAX7 in human muscle cells using the DNA plasmid transfection significantly enhanced wound recovery. PAX7 induced 70% wound closure compared to 20% controls and provided significant protection against H₂O₂-induced oxidative stress (cell viability increased from 40% to 80%). Overall, these results indicate the promising potential of PAX7 gene therapy as a targeted intervention to activate muscle cell regeneration and protect from cellular damage in injured muscle tissues.

Biology

Investigating User Perceptions, Ethical Challenges, and Expectations Regarding Brain-Computer Interfaces (BCIs) for Imagined Speech: A Mixed-Methods Protocol

ANGELIKI SPYROPOULOU · Aug 20, 2026

Brain-computer interfaces that translate internal thoughts into spoken words offer life-changing potential for people with severe speech impairments. However, while algorithm accuracy continues to improve, critical questions remain about how real people feel about using this technology every day. This 12-month study combines a quantitative survey with in-depth interviews involving patients, caregivers, neuroscientists, and ethics experts. The project explores practical user needs—such as acceptable accuracy levels and training time—while addressing deep worries about accidental thought leakage and brain data privacy. Ultimately, the goal is to provide engineers with clear, human-first guidelines to build BCIs that feel natural, safe, and truly respectful of user control.

NeurolinguisticsBrain-Computer InterfacesNeural SignalsImagined SpeechEEG Decoding

Designing Reliable Cryptocurrency Payment Infrastructure for Online Businesses: A Technical Review

Cryptoway · Aug 20, 2026

A technical review of cryptocurrency payment infrastructure for online businesses, covering checkout, invoices, blockchain monitoring, payment statuses, webhooks, reconciliation, stablecoin settlement, and automated payouts. The article also examines common operational failures and presents Cryptoway as a practical implementation example.

FintechWeb3Crypto PaymentsBlockchainCryptocurrency

NeuroRAG: Polychronous Multimodal Episodic Memory

Sujal Srivastava · Aug 15, 2026

Modern enterprise information systems contain heterogeneous streams of information that differ fundamentally in representation, temporal structure, and semantics. Relational databases encode structured attributes and transactions; knowledge graphs encode entities and relations; textual systems encode sequential symbolic information; telemetry and event streams additionally encode temporal dynamics. Conventional memory systems typically transform these modalities into a common vector space and subsequently perform similarity search, graph traversal, or learned re- trieval. Such approaches provide effective retrieval but do not naturally model one-shot associative learning, temporal binding, pattern completion, continual online learning, or biologically inspired memory consolidation. This work proposes a Polychronous Multimodal Episodic Memory (PMEM) architecture based on a spiking neural substrate inspired by the entorhinal cortex (EC), dentate gyrus (DG), hip- pocampal CA3, and CA1. Heterogeneous modalities are independently transformed into tempo- rally structured spike trains and converged into a common entorhinal representation. The DG performs sparse pattern separation, while recurrent CA3 dynamics form autoassociative attractor states capable of completing memories from partial or cross-modal cues. Spike-timing-dependent plasticity (STDP), neuromodulatory gating, synaptic delays, and polychronous convergence pro- vide mechanisms for rapid associative binding. CA1 provides a learned readout from the latent hippocampal state back to modality-specific representations. Subsequent extensions introduce episodic temporal sequences, replay-based consolidation, continual learning, homeostatic plastic- ity, modular scaling, and cross-modal retrieval. The resulting system is not intended to replace relational databases, graph databases, or lan- guage models. Instead, it defines a neural associative memory substrate operating over these systems, in which structured records, graph relations, and textual episodes become temporally en- coded neural events. The central research hypothesis is that multimodal information can be bound through spike timing and recurrent dynamics without requiring a single shared semantic embed- ding or an explicit retrieval index. The current prototype demonstrates encoder reconstruction, CA3 pattern completion, multimodal binding, engram stability, novelty-sensitive plasticity, and continuous two-stage encoding; however, several components remain prototype-level, particularly pure neural retrieval without symbolic assistance, large-scale capacity, semantic text encoding, continual consolidation, and rigorous comparison against modern memory baselines

COMPUTER SCIENCE AND ENGINEERING

How Does Vagal Signaling Shape the Brain's Threat Response?

Arya J Gowda · Aug 15, 2026

Anxiety and fear responses have long been considered as brain driven processes but recent studies show that the gut also plays a crucial role by communicating through the vagus nerve, as a contributing factor. This review examines evidence from vagal deafferentation, gut infection, probiotic administration, dysbiosis(imbalanced but still-present microbiome), and vagus nerve stimulation studies to understand how gut contributes to the threat response system and how it regulates it if it does . The evidence suggests that vagal involvement depends on whether the gut contains an active bacterial presence ie beneficial, harmful, or dysbiotic rather than based on the nature of the presence. It is also seen that the complete absence of gut microbiota produces effects independent of the vagus nerve which is presumed to be mediated through circulating metabolites. These findings support a model of the gut-brain axis as a bidirectional feedback regulation system.

Gut- BrainVagus nervegut MicrobiomeThreat Response systemanxiety

A User-Controlled Ultrasonic Obstruction Framework for Defending Against Voice Assistant and Covert Microphone Eavesdropping

Nithyashree · Aug 15, 2026

The widespread adoption of always-listening voice assistants, together with the growing availability of low-cost covert recording devices, has created two related but distinct audio privacy threats: authorized microphones that may capture more than a user intends, and unauthorized microphones that capture without consent at all. Existing defenses treat these threats in isolation. Voice-assistant privacy relies on manufacturer trust and after-the-fact data deletion, while covert device detection depends on specialized, single-technique tools that require manual expertise. This paper proposes a unified, user-controlled acoustic privacy framework built on broadband ultrasonic obstruction, an inaudible signal that disrupts the microphone hardware itself rather than the data pipeline behind it. The framework operates in two modes: a manually toggled Privacy Mode that immediately obstructs any nearby microphone, known or unknown, with activation and release fully controlled by the user; and an on-demand Bug Sweep Mode that detects unauthorized listening devices using network-traffic and optical signals available on a standard smartphone. We deliberately defer automatic, content-aware triggering, i.e. detecting sensitive conversation and obstructing without user initiation, to future work, avoiding the surveillance-to-prevent-surveillance paradox inherent in content-analysing privacy systems. This positions the proposed system as a practical, immediately deployable middle ground between passive OS-level permission indicators and expensive professional counter-surveillance equipment. Keywords: acoustic privacy, ultrasonic jamming, voice assistant privacy, covert device detection, zero-trust sensing, microphone obstruction

Voice assistantsprivacy

A Comparative Experimental Analysis of PostgreSQL and MongoDB

Primeswat · Aug 15, 2026

The selection of an appropriate database management system is an important consideration in modern software applications, particularly as data volumes and application workloads increase. Relational databases such as PostgreSQL provide structured data management, indexing, and strong transactional capabilities, while document-oriented NoSQL databases such as MongoDB emphasize flexible data representation and efficient write-oriented workloads. However, database performance is highly dependent on workload and experimental environment. This study presents a controlled experimental comparison of PostgreSQL and MongoDB under increasing data volumes. Four dataset sizes—10,000, 50,000, 100,000, and 500,000 records—were evaluated. The experiment measured bulk-write execution time and indexed point-read latency. Each configuration was executed five times. For the read experiment, 1,000 indexed point lookups were performed during each measurement. Mean, median, standard deviation, minimum, maximum, and coefficient of variation were considered during analysis. The results indicate that MongoDB achieved lower mean bulk-write execution times for the 10,000, 50,000, and 100,000 record datasets. At 500,000 records, PostgreSQL had a lower mean write time, although MongoDB's result was strongly affected by a single 109.34-second run. For indexed point reads, PostgreSQL produced lower mean latency at all four dataset sizes. These findings support the view that neither database can be considered universally superior; instead, database selection should be based on workload characteristics, indexing strategy, and performance requirements. Keywords: PostgreSQL, MongoDB, SQL, NoSQL, database performance, benchmarking, indexed reads, bulk writes, scalability, performance evaluation.

Comparative Analysis of PostgreSQL and MongoDB

R-INTEGRATE- AN INTEGRATED AI-DRIVEN INTELLIGENT ROAD MOBILITY AND TRAFFIC MANAGEMENT SYSTEM A proposed framework for real-time traffic and emergency management, road safety and user-oriented transportation

Ritesh Rangar · Aug 15, 2026

Author 1: Ritesh Rangar Author 2: Priyanka Singh Rajput Date: 15 August 2026 Abstract Traffic management in cities is becoming increasingly difficult because of the growing number of vehicles, congestion, accidents, road construction, poor road conditions and delays faced by emergency vehicles. Many technologies are already being used to deal with these problems, including traffic cameras, sensors, automated traffic enforcement, navigation systems and adaptive traffic signals. However, these technologies are often developed and operated for individual purposes. This paper proposes an integrated AI-driven road mobility system in which cameras, sensors, connected traffic signals and other data sources communicate with each other using IoT and a main central server. The server analyzes information collected from the road and takes appropriate actions according to the situation. For example, if an ambulance or fire vehicle is detected approaching an intersection, the system can identify its direction and provide appropriate signal priority. If one side of an intersection has a much larger vehicle queue, signal timing can be adjusted to improve traffic flow. Accidents, potholes, road construction and other road conditions can also be detected and reported. A connected website would act as the user-facing part of the system. It could display traffic conditions, congestion zones, construction information and traffic-signal status, while providing route options based on factors such as distance, congestion, expected signal delay and road condition. Instead of forcing every user to choose the same type of route, the system would allow users to decide what matters most to them, such as minimum distance, minimum travel time or better road conditions. Its main contribution is the integration of road detection, traffic management, emergency response, road maintenance and user information into one coordinated framework. The study also discusses the challenges of data accuracy, privacy, infrastructure requirements and the need for human or authorized verification in safety-critical and enforcement-related actions.

Emergency vehicle priorityAI ServerTrafficRoute SelectionRoad Safety